Beginning in approximately 1600 B.C., the Hittites, a people from the east conquered and destroyed Babylon. Hittite power subsequently waned, but, in the first half of the fourteenth century B.C., the Hittites reemerged, controlling an area that stretched from the Mediterranean Sea to the Persian Gulf. The military success of the Hittites has been attributed to their monopoly in iron production and to their use of the chariot. Nevertheless, in the twelfth century B.C., the Hittites were destroyed, and no great military power occupied Mesopotamia until the ninth century B.C.

One of the cities that flourished in the middle of the Tigris Valley during this period was that of Ashur, named after the sun-god of the Assyrians. The Assyrians occupied Babylon for a brief period in the thirteenth century B.C. Invasions of iron-producing peoples into the Near East and into the Aegean region in approximately 1200 B.C. disrupted the indigenous empires of Mesopotamia, but eventually the Assyrians were able to capitalize on the new alignments of power in the region. Because of what has been called "the barbarous and unspeakable cruelty of the Assyrians," the names of such Assyrian kings as Ashurnasirpal (883-859 B.C.), Tiglath-Pileser III (745- 727 B.C.), Sennacherib (704-681 B.C.), and Ashurbanipal (669-626 B.C.) continue to evoke images of powerful, militarily brilliant, but brutally savage conquerors.